SPONTANEOUSLY OCCURRING TUMORS IN EXPERIMENTAL ANIMALS

Scorpion Venom Pisoning in Experimental Animals

Transplantation of Spontaneously Occurring and Chemically Induced Lymphoid Tumors in Xenopus Laevis.

Two spontaneous and three methylcholanthrene-induced lymphoid tumors in the anuran amphibian Xenopus laevis laevis were transferred into the dorsal lymph sac, abdominal cavity, or under the abdominal skin of 93 immature or adult animals of the same species. Eighty-eight gave positive results, 76 with the persistence of the tumor at the implantation site and 70 with the development of visceral t...

Necrotizing effect of ethanedimethanesulfonate on spontaneously occurring Leydig cell tumors in old F344 rats.

Thirty 18-month-old male F344/DuCrj rats were divided into the following groups: 10 untreated controls; eight vehicle-injected controls; and 12 ethanedimethanesulfonate (EDS)-injected rats. Untreated controls were killed immediately to check for testicular tumor incidence. In rats of the test group, a 75-mg/kg dose of EDS dissolved in dimethyl sulfoxide:water (1:3) was injected i.p. At interval...

Variation in the distribution of a phthalocyanine photosensitizer in naturally occurring tumors of animals.

Photodynamic therapy of naturally occurring tumors in animals using a novel benzophenothiazine photosensitizer.

5-Ethylamino-9-diethylaminobenzo[a]phenothiazinium chloride (EtNBS) is a novel photodynamic therapy (PDT) photosensitizer with efficacy against experimental murine tumors. In this preliminary study, dogs and cats with naturally occurring tumors were treated with EtNBS-PDT to determine safety and efficacy. Fifteen treatments were performed on 13 animals (9 treatments in 8 cats and 6 treatments i...